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6-Substituted Pyrrolo[2,3-d]pyrimidine Thienoyl Regioisomers as Targeted Antifolates for Folate Receptor α and the Proton-Coupled Folate Transporter in Human Tumors

[Image: see text] 2-Amino-4-oxo-6-substituted-pyrrolo[2,3-d]-pyrimidine antifolate thiophene regioisomers of AGF94 (4) with a thienoyl side chain and three-carbon bridge lengths [AGF150 (5) and AGF154 (7)] were synthesized as potential antitumor agents. These analogues inhibited proliferation of Chi...

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Bibliografski detalji
Izdano u:J Med Chem
Glavni autori: Wang, Lei, Wallace, Adrianne, Raghavan, Sudhir, Deis, Siobhan M., Wilson, Mike R., Yang, Si, Polin, Lisa, White, Kathryn, Kushner, Juiwanna, Orr, Steven, George, Christina, O’Connor, Carrie, Hou, Zhanjun, Mitchell-Ryan, Shermaine, Dann, Charles E., Matherly, Larry H., Gangjee, Aleem
Format: Artigo
Jezik:Inglês
Izdano: 2015
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4714714/
https://ncbi.nlm.nih.gov/pubmed/26317331
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.jmedchem.5b00801
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