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Targeting Nonsquamous Nonsmall Cell Lung Cancer via the Proton-Coupled Folate Transporter with 6-Substituted Pyrrolo[2,3-d]Pyrimidine Thienoyl Antifolates

Pemetrexed (PMX) is a 5-substituted pyrrolo[2,3-d]pyrimidine antifolate used for therapy of nonsquamous nonsmall cell lung cancer (NS-NSCLC). PMX is transported by the reduced folate carrier (RFC) and proton-coupled folate transporter (PCFT). Unlike RFC, PCFT is active at acidic pH levels characteri...

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發表在:Mol Pharmacol
Main Authors: Wilson, Mike R., Hou, Zhanjun, Yang, Si, Polin, Lisa, Kushner, Juiwanna, White, Kathryn, Huang, Jenny, Ratnam, Manohar, Gangjee, Aleem, Matherly, Larry H.
格式: Artigo
語言:Inglês
出版: The American Society for Pharmacology and Experimental Therapeutics 2016
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC4809305/
https://ncbi.nlm.nih.gov/pubmed/26837243
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/mol.115.102798
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