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Dual targeting of epithelial ovarian cancer via folate receptor α and the proton-coupled folate transporter with 6-substituted pyrrolo[2,3-d]pyrimidine antifolates

Folate uptake in epithelial ovarian cancer (EOC) involves the reduced folate carrier (RFC) and the proton-coupled folate transporter (PCFT), both facilitative transporters, and folate receptor (FR) α. Whereas in primary EOC specimens, FRα is widely expressed and increases with tumor stage, PCFT was...

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Bibliographic Details
Published in:Mol Cancer Ther
Main Authors: Hou, Zhanjun, Gattoc, Leda, O’Connor, Carrie, Yang, Si, Wallace-Povirk, Adrianne, George, Christina, Orr, Steve, Polin, Lisa, White, Kathryn, Kushner, Juiwanna, Morris, Robert T., Gangjee, Aleem, Matherly, Larry H.
Format: Artigo
Language:Inglês
Published: 2017
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5443351/
https://ncbi.nlm.nih.gov/pubmed/28138029
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1535-7163.MCT-16-0444
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