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Therapeutic Targeting of a Novel 6-Substituted Pyrrolo [2,3-d]pyrimidine Thienoyl Antifolate to Human Solid Tumors Based on Selective Uptake by the Proton-Coupled Folate Transporter

The proton-coupled folate transporter (PCFT) is a proton-folate symporter with an acidic pH optimum. By real-time reverse transcription-polymerase chain reaction, PCFT was expressed in the majority of 53 human tumor cell lines, with the highest levels in Caco-2 (colorectal adenocarcinoma), SKOV3 (ov...

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Detalhes bibliográficos
Main Authors: Kugel Desmoulin, Sita, Wang, Lei, Hales, Eric, Polin, Lisa, White, Kathryn, Kushner, Juiwanna, Stout, Mark, Hou, Zhanjun, Cherian, Christina, Gangjee, Aleem, Matherly, Larry H.
Formato: Artigo
Idioma:Inglês
Publicado em: The American Society for Pharmacology and Experimental Therapeutics 2011
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3228537/
https://ncbi.nlm.nih.gov/pubmed/21940787
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/mol.111.073833
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