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Structure–Activity Profiles of Novel 6-Substituted Pyrrolo[2,3-d]pyrimidine Thienoyl Antifolates with Modified Amino Acids for Cellular Uptake by Folate Receptors α and β and the Proton-Coupled Folate Transporter

[Image: see text] Structure–activity relationships for cellular uptake and inhibition of cell proliferation were studied for 2-amino-4-oxo-6-substituted pyrrolo[2,3-d]pyrimidine thienoyl antifolates in which the terminal l-glutamate of the parent structure (7) was replaced by natural or unnatural am...

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Detalhes bibliográficos
Main Authors: Golani, Lalit K., George, Christina, Zhao, Sai, Raghavan, Sudhir, Orr, Steven, Wallace, Adrianne, Wilson, Mike R., Hou, Zhanjun, Matherly, Larry H., Gangjee, Aleem
Formato: Artigo
Idioma:Inglês
Publicado em: American Chemical Society 2014
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4191586/
https://ncbi.nlm.nih.gov/pubmed/25234128
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm501113m
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