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The Major Facilitative Folate Transporters Solute Carrier 19A1 and Solute Carrier 46A1: Biology and Role in Antifolate Chemotherapy of Cancer

This review summarizes the biology of the major facilitative membrane transporters, the reduced folate carrier (RFC) (Solute Carrier 19A1) and the proton-coupled folate transporter (PCFT) (Solute Carrier 46A1). Folates are essential vitamins, and folate deficiency contributes to a variety of health...

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Библиографические подробности
Главные авторы: Matherly, Larry H., Wilson, Mike R., Hou, Zhanjun
Формат: Artigo
Язык:Inglês
Опубликовано: The American Society for Pharmacology and Experimental Therapeutics 2014
Предметы:
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC3965896/
https://ncbi.nlm.nih.gov/pubmed/24396145
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/dmd.113.055723
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