Role of Lysine 411 in Substrate Carboxyl Group Binding to the Human Reduced Folate Carrier, as Determined by Site-directed Mutagenesis and Affinity Inhibition

Documents similaires

• Synthesis and biological activity of a novel series of 6-substituted thieno[2,3-d]pyrimidine antifolate inhibitors of purine biosynthesis with selectivity for high affinity folate receptors over the reduced folate carrier and proton-coupled folate transporter for cellular entry
  par: Deng, Yijun, et autres
  Publié: (2009)
• Substrate-specific binding and conformational changes involving Ser(313) and transmembrane domain 8 of the human reduced folate carrier, as determined by site-directed mutagenesis and protein cross-linking
  par: Hou, Zhanjun, et autres
  Publié: (2010)
• Synthesis and Discovery of High Affinity Folate Receptor-Specific Glycinamide Ribonucleotide Formyltransferase Inhibitors With Antitumor Activity
  par: Deng, Yijun, et autres
  Publié: (2008)
• Synthesis and biological activity of a novel series of 6-substituted pyrrolo[2,3-d]pyrimidine thienoyl antifolate inhibitors of purine biosynthesis with selectivity for high affinity folate receptors and the proton-coupled folate transporter over the reduced folate carrier for cellular entry(†)
  par: Wang, Lei, et autres
  Publié: (2010)
• Development and Validation of Chemical Features-Based Proton-Coupled Folate Transporter/Activity and Reduced Folate Carrier/Activity Models (Pharmacophores)
  par: Shah, Khushbu, et autres
  Publié: (2018)