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The promise and challenges of exploiting the proton-coupled folate transporter for selective therapeutic targeting of cancer

This review considers the “promise” of exploiting the proton-coupled folate transporter (PCFT) for selective therapeutic targeting of cancer. PCFT was discovered in 2006 and was identified as the principal folate transporter involved in the intestinal absorption of dietary folates. The recognition t...

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Detalhes bibliográficos
Publicado no:Cancer Chemother Pharmacol
Main Authors: Matherly, Larry H., Hou, Zhanjun, Gangjee, Aleem
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5756103/
https://ncbi.nlm.nih.gov/pubmed/29127457
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00280-017-3473-8
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