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Structure–activity correlations for three pyrido[2,3-d]pyrimidine antifolates binding to human and Pneumocystis carinii dihydrofolate reductase
To further define the interactions that enhance the selectivity of binding and to directly compare the binding of the most potent analogue {N (6)-methyl-N (6)-(3,4,5-trifluorophenyl)pyrido[2,3-d]pyrimidine-2,4,6-triamine; compound 26} in the series of bicyclic pyrido[2,3-d]pyrimidine analogues of pi...
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| Publicado no: | Acta Crystallogr F Struct Biol Commun |
|---|---|
| Main Authors: | , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
International Union of Crystallography
2015
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4461351/ https://ncbi.nlm.nih.gov/pubmed/26057816 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1107/S2053230X15008468 |
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