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Kinetic and Structural Analysis for Potent Antifolate Inhibition of Pneumocystis jirovecii, Pneumocystis carinii, and Human Dihydrofolate Reductases and Their Active-Site Variants

A major concern of immunocompromised patients, in particular those with AIDS, is susceptibility to infection caused by opportunistic pathogens such as Pneumocystis jirovecii, which is a leading cause of pneumonia in immunocompromised patients. We report the first kinetic and structural data for 2,4-...

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Detalhes bibliográficos
Main Authors: Cody, Vivian, Pace, Jim, Queener, Sherry F., Adair, Ona O., Gangjee, Aleem
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2013
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3716164/
https://ncbi.nlm.nih.gov/pubmed/23545530
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00172-13
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