Trimethoprim Resistance of Dihydrofolate Reductase Variants from Clinical Isolates of Pneumocystis jirovecii

Pneumocystis jirovecii is an opportunistic pathogen that causes serious pneumonia in immunosuppressed patients. Standard therapy and prophylaxis include trimethoprim (TMP)-sulfamethoxazole; trimethoprim in this combination targets dihydrofolate reductase (DHFR). Fourteen clinically observed variants...

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Bibliographische Detailangaben
Hauptverfasser: Queener, S. F., Cody, V., Pace, J., Torkelson, P., Gangjee, A.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Microbiology 2013
Schlagworte:
Mechanisms of Resistance
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3811448/
https://ncbi.nlm.nih.gov/pubmed/23896474
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01161-13
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