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Trimethoprim Resistance of Dihydrofolate Reductase Variants from Clinical Isolates of Pneumocystis jirovecii

Pneumocystis jirovecii is an opportunistic pathogen that causes serious pneumonia in immunosuppressed patients. Standard therapy and prophylaxis include trimethoprim (TMP)-sulfamethoxazole; trimethoprim in this combination targets dihydrofolate reductase (DHFR). Fourteen clinically observed variants...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Queener, S. F., Cody, V., Pace, J., Torkelson, P., Gangjee, A.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: American Society for Microbiology 2013
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC3811448/
https://ncbi.nlm.nih.gov/pubmed/23896474
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01161-13
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