Correlations of Inhibitor Kinetics for Pneumocystis jirovecii and Human Dihydrofolate Reductase with Structural Data for Human Active Site Mutant Enzyme Complexes

To understand the role of specific active site residues in conferring selective dihydrofolate reductase (DHFR) inhibition from pathogenic organisms such as Pneumocystis carinii (pc) or Pneumocystis jirovecii (pj), the causative agent in AIDS pneumonia, it is necessary to evaluate the role of these r...

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Hlavní autoři: Cody, Vivian, Pace, Jim, Makin, Jennifer, Piraino, Jennifer, Queener, Sherry F., Rosowsky, Andre
Médium: Artigo
Jazyk:Inglês
Vydáno: 2009
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2765523/
https://ncbi.nlm.nih.gov/pubmed/19196009
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi801960h
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