Mutations of Pneumocystis jirovecii Dihydrofolate Reductase Associated with Failure of Prophylaxis

Most drugs used for prevention and treatment of Pneumocystis jirovecii pneumonia target enzymes involved in the biosynthesis of folic acid, i.e., dihydropteroate synthase (DHPS) and dihydrofolate reductase (DHFR). Emergence of P. jirovecii drug resistance has been suggested by the association betwee...

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Autori principali: Nahimana, Aimable, Rabodonirina, Meja, Bille, Jacques, Francioli, Patrick, Hauser, Philippe M.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Microbiology 2004
Soggetti:
Mechanisms of Resistance
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC525445/
https://ncbi.nlm.nih.gov/pubmed/15504856
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.48.11.4301-4305.2004
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