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Mutations of Pneumocystis jirovecii Dihydrofolate Reductase Associated with Failure of Prophylaxis

Most drugs used for prevention and treatment of Pneumocystis jirovecii pneumonia target enzymes involved in the biosynthesis of folic acid, i.e., dihydropteroate synthase (DHPS) and dihydrofolate reductase (DHFR). Emergence of P. jirovecii drug resistance has been suggested by the association betwee...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Nahimana, Aimable, Rabodonirina, Meja, Bille, Jacques, Francioli, Patrick, Hauser, Philippe M.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: American Society for Microbiology 2004
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC525445/
https://ncbi.nlm.nih.gov/pubmed/15504856
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.48.11.4301-4305.2004
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