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Mutations of Pneumocystis jirovecii Dihydrofolate Reductase Associated with Failure of Prophylaxis
Most drugs used for prevention and treatment of Pneumocystis jirovecii pneumonia target enzymes involved in the biosynthesis of folic acid, i.e., dihydropteroate synthase (DHPS) and dihydrofolate reductase (DHFR). Emergence of P. jirovecii drug resistance has been suggested by the association betwee...
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| Main Authors: | , , , , |
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| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
American Society for Microbiology
2004
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC525445/ https://ncbi.nlm.nih.gov/pubmed/15504856 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.48.11.4301-4305.2004 |
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