A carregar...

N9-Substituted 2,4-Diaminoquinazolines: Synthesis and Biological Evaluation of Lipophilic Inhibitors of Pneumocystis carinii and Toxoplasma gondii Dihydrofolate Reductase

N9-substituted 2,4-diaminoquinazolines were synthesized and evaluated as inhibitors of Pneumocystis carinii (pc) and Toxoplasma gondii (tg) dihydrofolate reductase (DHFR). Reduction of commercially available 2,4-diamino-6-nitroquinazoline 14 with Raney nickel afforded 2,4,6-triaminoquinazoline 15. R...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Main Authors: Gangjee, Aleem, Adair, Ona O., Pagley, Michelle, Queener, Sherry F.
Formato: Artigo
Idioma:Inglês
Publicado em: 2008
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3885247/
https://ncbi.nlm.nih.gov/pubmed/18771252
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm800694g
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!