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Myc and mTOR converge on a common node in protein synthesis control that confers synthetic lethality in Myc-driven cancers

Myc is one of the most commonly deregulated oncogenes in human cancer, yet therapies directly targeting Myc hyperactivation are not presently available in the clinic. The evolutionarily conserved function of Myc in modulating protein synthesis control is critical to the Myc oncogenic program. Indeed...

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Autori principali: Pourdehnad, Michael, Truitt, Morgan L., Siddiqi, Imran N., Ducker, Gregory S., Shokat, Kevan M., Ruggero, Davide
Natura: Artigo
Lingua:Inglês
Pubblicazione: National Academy of Sciences 2013
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3718086/
https://ncbi.nlm.nih.gov/pubmed/23803853
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1310230110
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