Metabolic Profiling Reveals a Dependency of Human Metastatic Breast Cancer on Mitochondrial Serine and One-Carbon Unit Metabolism

Breast cancer is the most common cancer among American women and a major cause of mortality. To identify metabolic pathways as potential targets to treat metastatic breast cancer, we performed metabolomics profiling on breast cancer cell line MDA-MB-231 and its tissue-tropic metastatic subclones. He...

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Detalhes bibliográficos
Publicado no:Mol Cancer Res
Main Authors: Li, Albert M., Ducker, Gregory S., Li, Yang, Seoane, Jose A., Xiao, Yiren, Melemenidis, Stavros, Zhou, Yiren, Liu, Ling, Vanharanta, Sakari, Graves, Edward E., Rankin, Erinn B., Curtis, Christina, Massagué, Joan, Rabinowitz, Joshua D., Thompson, Craig B., Ye, Jiangbin
Formato: Artigo
Idioma:Inglês
Publicado em: 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7127984/
https://ncbi.nlm.nih.gov/pubmed/31941752
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1541-7786.MCR-19-0606
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