Metabolic Profiling Reveals a Dependency of Human Metastatic Breast Cancer on Mitochondrial Serine and One-Carbon Unit Metabolism

Breast cancer is the most common cancer among American women and a major cause of mortality. To identify metabolic pathways as potential targets to treat metastatic breast cancer, we performed metabolomics profiling on breast cancer cell line MDA-MB-231 and its tissue-tropic metastatic subclones. He...

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Veröffentlicht in:Mol Cancer Res
Hauptverfasser: Li, Albert M., Ducker, Gregory S., Li, Yang, Seoane, Jose A., Xiao, Yiren, Melemenidis, Stavros, Zhou, Yiren, Liu, Ling, Vanharanta, Sakari, Graves, Edward E., Rankin, Erinn B., Curtis, Christina, Massagué, Joan, Rabinowitz, Joshua D., Thompson, Craig B., Ye, Jiangbin
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2020
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7127984/
https://ncbi.nlm.nih.gov/pubmed/31941752
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1541-7786.MCR-19-0606
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