Simultaneous Targeting of PARP1 and RAD52 Triggers Dual Synthetic Lethality in BRCA-Deficient Tumor Cells

PARP inhibitors (PARPis) have been used to induce synthetic lethality in BRCA-deficient tumors in clinical trials with limited success. We hypothesized that RAD52-mediated DNA repair remains active in PARPi-treated BRCA-deficient tumor cells and that targeting RAD52 should enhance the synthetic leth...

पूर्ण विवरण

में बचाया:
ग्रंथसूची विवरण
में प्रकाशित:Cell Rep
मुख्य लेखकों: Sullivan-Reed, Katherine, Bolton-Gillespie, Elisabeth, Dasgupta, Yashodhara, Langer, Samantha, Siciliano, Micheal, Nieborowska-Skorska, Margaret, Hanamshet, Kritika, Belyaeva, Elizaveta A., Bernhardy, Andrea J., Lee, Jaewong, Moore, Morgan, Zhao, Huaqing, Valent, Peter, Matlawska-Wasowska, Ksenia, Müschen, Markus, Bhatia, Smita, Bhatia, Ravi, Johnson, Neil, Wasik, Mariusz A., Mazin, Alexander V., Skorski, Tomasz
स्वरूप: Artigo
भाषा:Inglês
प्रकाशित: 2018
विषय:
Article
ऑनलाइन पहुंच:https://ncbi.nlm.nih.gov/pmc/articles/PMC6082171/
https://ncbi.nlm.nih.gov/pubmed/29898385
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2018.05.034
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