IGH/MYC Translocation Associates with BRCA2 Deficiency and Synthetic Lethality to PARP1 Inhibitors

Burkitt lymphoma/leukemia (BL) cells carry t(8;14)(q24;q32) chromosomal translocation encoding IGH/MYC, which results in the constitutive expression of the MYC oncogene. Here, it is demonstrated that untreated and cytarabine (AraC)-treated IGH/MYC-positive BL cells accumulate a high number of potent...

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Detalhes bibliográficos
Publicado no:Mol Cancer Res
Main Authors: Maifrede, Silvia, Martin, Kayla A., Podszywalow-Bartnicka, Paulina, Sullivan, Katherine, Langer, Samantha K., Nejati, Reza, Dasgupta, Yashodhara, Hulse, Michael, Gritsyuk, Daniel, Nieborowska-Skorska, Margaret, Lupey-Green, Lena N., Zhao, Huaqing, Piwocka, Katarzyna, Wasik, Mariusz, Tempera, Italo, Skorski, Tomasz
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5540764/
https://ncbi.nlm.nih.gov/pubmed/28634224
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1541-7786.MCR-16-0468
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