Characterization of homing endonuclease binding and cleavage specificities using yeast surface display SELEX (YSD-SELEX)

Por Jacoby, Kyle, Lambert, Abigail R., Scharenberg, Andrew M.
Publicado no Nucleic Acids Res (2017)

Engineering and Flow-Cytometric Analysis of Chimeric LAGLIDADG Homing Endonucleases from Homologous I-OnuI-Family Enzymes

Por Baxter, Sarah K., Scharenberg, Andrew M., Lambert, Abigail R.
Publicado em 2014

Folding, DNA recognition and function of GIY-YIG endonucleases: crystal structures of R.Eco29kI

Por Mak, Amanda Nga-Sze, Lambert, Abigail R., Stoddard, Barry L.
Publicado em 2010

Flow Cytometric Assays for Interrogating LAGLIDADG Homing Endonuclease DNA-Binding and Cleavage Properties

Por Baxter, Sarah K., Lambert, Abigail R., Scharenberg, Andrew M., Jarjour, Jordan
Publicado em 2013

Optimization of protein thermostability and exploitation of recognition behavior to engineer altered protein-DNA recognition

Por Lambert, Abigail R., Hallinan, Jazmine P., Werther, Rachel, Glöw, Dawid, Stoddard, Barry L.
Publicado no Structure (2020)

LAHEDES: the LAGLIDADG homing endonuclease database and engineering server

Por Taylor, Gregory K., Petrucci, Lucas H., Lambert, Abigail R., Baxter, Sarah K., Jarjour, Jordan, Stoddard, Barry L.
Publicado em 2012

Structures of the rare-cutting restriction endonuclease NotI reveal a novel metal binding fold involved in DNA recognition

Por Lambert, Abigail R., Sussman, Django, Shen, Betty, Maunus, Robert, Nix, Jay, Samuelson, James, Xu, Shuang-yong, Stoddard, Barry L.
Publicado em 2008

Tuning DNA binding affinity and cleavage specificity of an engineered gene-targeting nuclease via surface display, flow cytometry and cellular analyses

Por Niyonzima, Nixon, Lambert, Abigail R., Werther, Rachel, De Silva Feelixge, Harshana, Roychoudhury, Pavitra, Greninger, Alexander L., Stone, Daniel, Stoddard, Barry L., Jerome, Keith R.
Publicado no Protein Eng Des Sel (2017)

Engineering domain fusion chimeras from I-OnuI family LAGLIDADG homing endonucleases

Por Baxter, Sarah, Lambert, Abigail R., Kuhar, Ryan, Jarjour, Jordan, Kulshina, Nadia, Parmeggiani, Fabio, Danaher, Patrick, Gano, Jacob, Baker, David, Stoddard, Barry L., Scharenberg, Andrew M.
Publicado em 2012

Crystallographic analyses illustrate significant plasticity and efficient recoding of meganuclease target specificity

Por Werther, Rachel, Hallinan, Jazmine P., Lambert, Abigail R., Havens, Kyle, Pogson, Mark, Jarjour, Jordan, Galizi, Roberto, Windbichler, Nikolai, Crisanti, Andrea, Nolan, Tony, Stoddard, Barry L.
Publicado no Nucleic Acids Res (2017)

Tapping natural reservoirs of homing endonucleases for targeted gene modification

Por Takeuchi, Ryo, Lambert, Abigail R., Mak, Amanda Nga-Sze, Jacoby, Kyle, Dickson, Russell J., Gloor, Gregory B., Scharenberg, Andrew M., Edgell, David R., Stoddard, Barry L.
Publicado em 2011

Indirect DNA sequence recognition and its impact on nuclease cleavage activity

Por Lambert, Abigail R., Hallinan, Jazmine P., Shen, Betty W., Chik, Jennifer K., Bolduc, Jill M., Kulshina, Nadia, Robins, Lori I., Kaiser, Brett K., Jarjour, Jordan, Havens, Kyle, Scharenberg, Andrew M., Stoddard, Barry L.
Publicado no Structure (2016)

Computational design of an enzyme catalyst for a stereoselective bimolecular Diels-Alder reaction

Por Siegel, Justin B., Zanghellini, Alexandre, Lovick, Helena M., Kiss, Gert, Lambert, Abigail R., St.Clair, Jennifer L., Gallaher, Jasmine L., Hilvert, Donald, Gelb, Michael H., Stoddard, Barry L., Houk, Kendall N., Michael, Forrest E., Baker, David
Publicado em 2010

Coupling endonucleases with DNA end-processing enzymes to drive gene disruption

Por Certo, Michael T, Gwiazda, Kamila S, Kuhar, Ryan, Sather, Blythe, Curinga, Gabrielle, Mandt, Tyler, Brault, Michelle, Lambert, Abigail R, Baxter, Sarah K, Jacoby, Kyle, Ryu, Byoung Y, Kiem, Hans-Peter, Gouble, Agnes, Paques, Frederic, Rawlings, David J, Scharenberg, Andrew M
Publicado em 2012