Crystallographic analyses illustrate significant plasticity and efficient recoding of meganuclease target specificity

The retargeting of protein–DNA specificity, outside of extremely modular DNA binding proteins such as TAL effectors, has generally proved to be quite challenging. Here, we describe structural analyses of five different extensively retargeted variants of a single homing endonuclease, that have been s...

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Dades bibliogràfiques
Publicat a:Nucleic Acids Res
Autors principals: Werther, Rachel, Hallinan, Jazmine P., Lambert, Abigail R., Havens, Kyle, Pogson, Mark, Jarjour, Jordan, Galizi, Roberto, Windbichler, Nikolai, Crisanti, Andrea, Nolan, Tony, Stoddard, Barry L.
Format: Artigo
Idioma:Inglês
Publicat: Oxford University Press 2017
Matèries:
Synthetic Biology and Bioengineering
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5737575/
https://ncbi.nlm.nih.gov/pubmed/28637173
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkx544
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