Crystallographic analyses illustrate significant plasticity and efficient recoding of meganuclease target specificity

The retargeting of protein–DNA specificity, outside of extremely modular DNA binding proteins such as TAL effectors, has generally proved to be quite challenging. Here, we describe structural analyses of five different extensively retargeted variants of a single homing endonuclease, that have been s...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:Nucleic Acids Res
Egile Nagusiak: Werther, Rachel, Hallinan, Jazmine P., Lambert, Abigail R., Havens, Kyle, Pogson, Mark, Jarjour, Jordan, Galizi, Roberto, Windbichler, Nikolai, Crisanti, Andrea, Nolan, Tony, Stoddard, Barry L.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: Oxford University Press 2017
Gaiak:
Synthetic Biology and Bioengineering
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC5737575/
https://ncbi.nlm.nih.gov/pubmed/28637173
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkx544
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