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Optimization of protein thermostability and exploitation of recognition behavior to engineer altered protein-DNA recognition
The redesign of a macromolecular binding interface and corresponding alteration of recognition specificity is a challenging endeavor that remains recalcitrant to computational approaches. This is particularly true for the redesign of DNA binding specificity, which is highly dependent upon bending, h...
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| Udgivet i: | Structure |
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| Main Authors: | , , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2020
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7347439/ https://ncbi.nlm.nih.gov/pubmed/32359399 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.str.2020.04.009 |
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