Optimization of protein thermostability and exploitation of recognition behavior to engineer altered protein-DNA recognition

The redesign of a macromolecular binding interface and corresponding alteration of recognition specificity is a challenging endeavor that remains recalcitrant to computational approaches. This is particularly true for the redesign of DNA binding specificity, which is highly dependent upon bending, h...

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Bibliographic Details
Published in:Structure
Main Authors: Lambert, Abigail R., Hallinan, Jazmine P., Werther, Rachel, Glöw, Dawid, Stoddard, Barry L.
Format: Artigo
Language:Inglês
Published: 2020
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7347439/
https://ncbi.nlm.nih.gov/pubmed/32359399
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.str.2020.04.009
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