Crystallographic analyses illustrate significant plasticity and efficient recoding of meganuclease target specificity

The retargeting of protein–DNA specificity, outside of extremely modular DNA binding proteins such as TAL effectors, has generally proved to be quite challenging. Here, we describe structural analyses of five different extensively retargeted variants of a single homing endonuclease, that have been s...

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Bibliografiske detaljer
Udgivet i:Nucleic Acids Res
Main Authors: Werther, Rachel, Hallinan, Jazmine P., Lambert, Abigail R., Havens, Kyle, Pogson, Mark, Jarjour, Jordan, Galizi, Roberto, Windbichler, Nikolai, Crisanti, Andrea, Nolan, Tony, Stoddard, Barry L.
Format: Artigo
Sprog:Inglês
Udgivet: Oxford University Press 2017
Fag:
Synthetic Biology and Bioengineering
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5737575/
https://ncbi.nlm.nih.gov/pubmed/28637173
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkx544
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