Crystallographic analyses illustrate significant plasticity and efficient recoding of meganuclease target specificity

The retargeting of protein–DNA specificity, outside of extremely modular DNA binding proteins such as TAL effectors, has generally proved to be quite challenging. Here, we describe structural analyses of five different extensively retargeted variants of a single homing endonuclease, that have been s...

Descrición completa

Gardado en:
Detalles Bibliográficos
Publicado en:Nucleic Acids Res
Main Authors: Werther, Rachel, Hallinan, Jazmine P., Lambert, Abigail R., Havens, Kyle, Pogson, Mark, Jarjour, Jordan, Galizi, Roberto, Windbichler, Nikolai, Crisanti, Andrea, Nolan, Tony, Stoddard, Barry L.
Formato: Artigo
Idioma:Inglês
Publicado: Oxford University Press 2017
Assuntos:
Synthetic Biology and Bioengineering
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5737575/
https://ncbi.nlm.nih.gov/pubmed/28637173
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkx544
Tags: Engadir etiqueta
Sen Etiquetas, Sexa o primeiro en etiquetar este rexistro!

Títulos similares