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Engineering and Flow-Cytometric Analysis of Chimeric LAGLIDADG Homing Endonucleases from Homologous I-OnuI-Family Enzymes

LAGLIDADG homing endonucleases (LHEs) are valuable tools for genome engineering, and our ability to alter LHE target site specificity is rapidly evolving. However, widespread use of these enzymes is limited due to the small number of available engineering scaffolds, each requiring extensive redesign...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Baxter, Sarah K., Scharenberg, Andrew M., Lambert, Abigail R.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2014
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4134777/
https://ncbi.nlm.nih.gov/pubmed/24510269
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/978-1-62703-968-0_14
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