Indirect DNA sequence recognition and its impact on nuclease cleavage activity

LAGLIDADG meganucleases are DNA cleaving enzymes used for genome engineering. While their cleavage specificity can be altered using several protein engineering and selection strategies, their overall ‘targetability’ is limited by highly specific indirect recognition of the central four basepairs wit...

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Detalhes bibliográficos
Publicado no:Structure
Main Authors: Lambert, Abigail R., Hallinan, Jazmine P., Shen, Betty W., Chik, Jennifer K., Bolduc, Jill M., Kulshina, Nadia, Robins, Lori I., Kaiser, Brett K., Jarjour, Jordan, Havens, Kyle, Scharenberg, Andrew M., Stoddard, Barry L.
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4899242/
https://ncbi.nlm.nih.gov/pubmed/27133026
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.str.2016.03.024
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