Indirect DNA sequence recognition and its impact on nuclease cleavage activity

LAGLIDADG meganucleases are DNA cleaving enzymes used for genome engineering. While their cleavage specificity can be altered using several protein engineering and selection strategies, their overall ‘targetability’ is limited by highly specific indirect recognition of the central four basepairs wit...

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Bibliografische gegevens
Gepubliceerd in:Structure
Hoofdauteurs: Lambert, Abigail R., Hallinan, Jazmine P., Shen, Betty W., Chik, Jennifer K., Bolduc, Jill M., Kulshina, Nadia, Robins, Lori I., Kaiser, Brett K., Jarjour, Jordan, Havens, Kyle, Scharenberg, Andrew M., Stoddard, Barry L.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2016
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4899242/
https://ncbi.nlm.nih.gov/pubmed/27133026
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.str.2016.03.024
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