Acute Overexpression of Myc in Intestinal Epithelium Recapitulates Some but Not All the Changes Elicited by Wnt/β-Catenin Pathway Activation

door Finch, Andrew J., Soucek, Laura, Junttila, Melissa R., Swigart, Lamorna Brown, Evan, Gerard I.
Gepubliceerd in 2009

Castration-Resistant Lgr5(+) Cells Are Long-Lived Stem Cells Required for Prostatic Regeneration

door Wang, Bu-er, Wang, Xi, Long, Jason E., Eastham-Anderson, Jeff, Firestein, Ron, Junttila, Melissa R.
Gepubliceerd in Stem Cell Reports (2015)

Distinct thresholds govern Myc’s biological output in vivo

door Daniel, J. Murphy, Junttila, Melissa R., Pouyet, Laurent, Karnezis, Anthony, Shchors, Ksenya, Bui, Duyen A., Brown-Swigart, Lamorna, Johnson, Leisa, Evan, Gerard. I.
Gepubliceerd in 2008

Selective activation of p53-mediated tumour suppression in high-grade tumours

door Junttila, Melissa R., Karnezis, Anthony, Garcia, Daniel, Madriles, Francesc, Kortlever, Roderik M., Rostker, Fanya, Brown-Swigart, Lamorna, Pham, David M., Seo, Youngho, Evan, Gerard I., Martins, Carla P.
Gepubliceerd in 2010

Quantification of Tumor Burden in a Genetically Engineered Mouse Model of Lung Cancer by Micro-CT and Automated Analysis()

door Barck, Kai H., Bou-Reslan, Hani, Rastogi, Ujjawal, Sakhuja, Timothy, Long, Jason E., Molina, Rafael, Lima, Anthony, Hamilton, Patricia, Junttila, Melissa R., Johnson, Leisa, Carano, Richard A.D.
Gepubliceerd in Transl Oncol (2015)

PME-1 protects ERK pathway activity from protein phosphatase 2A-mediated inactivation in human malignant glioma

door Puustinen, Pietri, Junttila, Melissa R., Vanhatupa, Sari, Sablina, Anna A., Hector, Melissa E., Teittinen, Kaisa, Raheem, Olayinka, Ketola, Kirsi, Lin, Shujun, Kast, Juergen, Haapasalo, Hannu, Hahn, William C., Westermarck, Jukka
Gepubliceerd in 2009

Kras mutant genetically engineered mouse models of human cancers are genomically heterogeneous

door Chung, Wei-Jen, Daemen, Anneleen, Cheng, Jason H., Long, Jason E., Cooper, Jonathan E., Wang, Bu-er, Tran, Christopher, Singh, Mallika, Gnad, Florian, Modrusan, Zora, Foreman, Oded, Junttila, Melissa R.
Gepubliceerd in Proc Natl Acad Sci U S A (2017)

Transcription factor Etv5 is essential for the maintenance of alveolar type II cells

door Zhang, Zhen, Newton, Kim, Kummerfeld, Sarah K., Webster, Joshua, Kirkpatrick, Donald S., Phu, Lilian, Eastham-Anderson, Jeffrey, Liu, Jinfeng, Lee, Wyne P., Wu, Jiansheng, Li, Hong, Junttila, Melissa R., Dixit, Vishva M.
Gepubliceerd in Proc Natl Acad Sci U S A (2017)

Manic Fringe deficiency imposes Jagged1 addiction to intestinal tumor cells

door López-Arribillaga, Erika, Rodilla, Verónica, Colomer, Carlota, Vert, Anna, Shelton, Amy, Cheng, Jason H., Yan, Bing, Gonzalez-Perez, Abel, Junttila, Melissa R., Iglesias, Mar, Torres, Ferran, Albanell, Joan, Villanueva, Alberto, Bigas, Anna, Siebel, Christian W., Espinosa, LLuís
Gepubliceerd in Nat Commun (2018)

A stromal niche defined by expression of the transcription factor Wilms tumor 1 mediates programming and homeostasis of cavity-resident macrophages

door Buechler, Matthew B., Kim, Ki-Wook, Onufer, Emily J., Williams, Jesse W., Little, Christine C., Dominguez, Claudia X., Li, Qingling, Sandoval, Wendy, Cooper, Jonathan E., Harris, Charles A., Junttila, Melissa R., Randolph, Gwendalyn J., Turley, Shannon J.
Gepubliceerd in Immunity (2019)

Oncogenic RAS pathway activation promotes resistance to anti-VEGF therapy through G-CSF–induced neutrophil recruitment

door Phan, Vernon T., Wu, Xiumin, Cheng, Jason H., Sheng, Rebecca X., Chung, Alicia S., Zhuang, Guanglei, Tran, Christopher, Song, Qinghua, Kowanetz, Marcin, Sambrone, Amy, Tan, Martha, Meng, Y. Gloria, Jackson, Erica L., Peale, Franklin V., Junttila, Melissa R., Ferrara, Napoleone
Gepubliceerd in 2013

Therapeutic resistance and susceptibility is shaped by cooperative multi-compartment tumor adaptation

door Long, Jason E., Wongchenko, Matthew J., Nickles, Dorothee, Chung, Wei-Jen, Wang, Bu-er, Riegler, Johannes, Li, Ji, Li, Qingling, Sandoval, Wendy, Eastham-Anderson, Jeff, Modrusan, Zora, Junttila, Teemu, Carano, Richard A. D., Foreman, Oded, Yan, Yibing, Junttila, Melissa R.
Gepubliceerd in Cell Death Differ (2019)

Senescence sensitivity of breast cancer cells is defined by positive feedback loop between CIP2A and E2F1

door Laine, Anni, Sihto, Harri, Come, Christophe, Rosenfeldt, Mathias T., Zwolinska, Aleksandra, Niemelä, Minna, Khanna, Anchit, Chan, Edward K., Kähäri, Veli-Matti, Kellokumpu-Lehtinen, Pirkko-Liisa, Sansom, Owen J., Evan, Gerard I., Junttila, Melissa R., Ryan, Kevin M., Marine, Jean-Christophe, Joensuu, Heikki, Westermarck, Jukka
Gepubliceerd in 2013

Combined MEK and ERK inhibition overcomes therapy-mediated pathway reactivation in RAS mutant tumors

door Merchant, Mark, Moffat, John, Schaefer, Gabriele, Chan, Jocelyn, Wang, Xi, Orr, Christine, Cheng, Jason, Hunsaker, Thomas, Shao, Lily, Wang, Stephanie J., Wagle, Marie-Claire, Lin, Eva, Haverty, Peter M., Shahidi-Latham, Sheerin, Ngu, Hai, Solon, Margaret, Eastham-Anderson, Jeffrey, Koeppen, Hartmut, Huang, Shih-Min A., Schwarz, Jacob, Belvin, Marcia, Kirouac, Daniel, Junttila, Melissa R.
Gepubliceerd in PLoS One (2017)

Correction: Combined MEK and ERK inhibition overcomes therapy-mediated pathway reactivation in RAS mutant tumors

door Merchant, Mark, Moffat, John, Schaefer, Gabriele, Chan, Jocelyn, Wang, Xi, Orr, Christine, Cheng, Jason, Hunsaker, Thomas, Shao, Lily, Wang, Stephanie J., Wagle, Marie-Claire, Lin, Eva, Haverty, Peter M., Shahidi-Latham, Sheerin, Ngu, Hai, Solon, Margaret, Eastham-Anderson, Jeffrey, Koeppen, Hartmut, Huang, Shih-Min A., Schwarz, Jacob, Belvin, Marcia, Kirouac, Daniel, Junttila, Melissa R.
Gepubliceerd in PLoS One (2018)

Target arm affinities determine preclinical efficacy and safety of anti-HER2/CD3 bispecific antibody

door Staflin, Karin, Zuch de Zafra, Christina L., Schutt, Leah K., Clark, Vanessa, Zhong, Fiona, Hristopoulos, Maria, Clark, Robyn, Li, Ji, Mathieu, Mary, Chen, Xiaocheng, Johnston, Jennifer, Low, Justin, Ybarra, Ryan, Slaga, Dionysos, Yang, Jihong, Ovacik, Meric, Dybdal, Noël O., Totpal, Klara, Junttila, Melissa R., Ellerman, Diego, Lee, Genee, Dennis, Mark S., Prell, Rodney, Junttila, Teemu T.
Gepubliceerd in JCI Insight (2020)

Randomized Phase Ib/II Study of Gemcitabine Plus Placebo or Vismodegib, a Hedgehog Pathway Inhibitor, in Patients With Metastatic Pancreatic Cancer

door Catenacci, Daniel V.T., Junttila, Melissa R., Karrison, Theodore, Bahary, Nathan, Horiba, Margit N., Nattam, Sreenivasa R., Marsh, Robert, Wallace, James, Kozloff, Mark, Rajdev, Lakshmi, Cohen, Deirdre, Wade, James, Sleckman, Bethany, Lenz, Heinz-Josef, Stiff, Patrick, Kumar, Pankaj, Xu, Peng, Henderson, Les, Takebe, Naoko, Salgia, Ravi, Wang, Xi, Stadler, Walter M., de Sauvage, Frederic J., Kindler, Hedy L.
Gepubliceerd in J Clin Oncol (2015)

RIP1 inhibition blocks inflammatory diseases but not tumor growth or metastases

door Patel, Snahel, Webster, Joshua D., Varfolomeev, Eugene, Kwon, Youngsu C., Cheng, Jason H., Zhang, Juan, Dugger, Debra L., Wickliffe, Kate E., Maltzman, Allie, Sujatha-Bhaskar, Swathi, Bir Kohli, Pawan, Ramaswamy, Sreema, Deshmukh, Gauri, Liederer, Bianca M., Fong, Rina, Hamilton, Greg, Lupardus, Patrick, Caplazi, Patrick, Lee, Wyne P., van Lookeren Campagne, Menno, Johnson, Adam, McKenzie, Brent S., Junttila, Melissa R., Newton, Kim, Vucic, Domagoj
Gepubliceerd in Cell Death Differ (2019)