Bub1 overexpression induces aneuploidy and tumor formation through Aurora B kinase hyperactivation

Por Ricke, Robin M., Jeganathan, Karthik B., van Deursen, Jan M.
Publicado em 2011

Whole chromosome instability caused by Bub1 insufficiency drives tumorigenesis through tumor suppressor gene loss of heterozygosity

Por Baker, Darren J., Jin, Fang, Jeganathan, Karthik B., van Deursen, Jan M.
Publicado em 2009

Nuclear pore protein NUP88 activates anaphase-promoting complex to promote aneuploidy

Por Naylor, Ryan M., Jeganathan, Karthik B., Cao, Xiuqi, van Deursen, Jan M.
Publicado no J Clin Invest (2016)

Overexpression of the E2 ubiquitin–conjugating enzyme UbcH10 causes chromosome missegregation and tumor formation

Por van Ree, Janine H., Jeganathan, Karthik B., Malureanu, Liviu, van Deursen, Jan M.
Publicado em 2010

Bub1 kinase activity drives error correction and mitotic checkpoint control but not tumor suppression

Por Ricke, Robin M., Jeganathan, Karthik B., Malureanu, Liviu, Harrison, Andrew M., van Deursen, Jan M.
Publicado em 2012

BubR1 N Terminus Acts as a Soluble Inhibitor of Cyclin B Degradation by APC/C(Cdc20) in Interphase

Por Malureanu, Liviu A., Jeganathan, Karthik B., Hamada, Masakazu, Wasilewski, Lisa, Davenport, James, van Deursen, Jan M.
Publicado em 2009

Pten regulates spindle pole movement through Dlg1-mediated recruitment of Eg5 to centrosomes

Por van Ree, Janine H., Nam, Hyun-Ja, Jeganathan, Karthik B., Kanakkanthara, Arun, van Deursen, Jan M.
Publicado no Nat Cell Biol (2016)

Early aging–associated phenotypes in Bub3/Rae1 haploinsufficient mice

Por Baker, Darren J., Jeganathan, Karthik B., Malureanu, Liviu, Perez-Terzic, Carmen, Terzic, Andre, van Deursen, Jan M.A.
Publicado em 2006

Rae1 is an essential mitotic checkpoint regulator that cooperates with Bub3 to prevent chromosome missegregation

Por Babu, J. Ramesh, Jeganathan, Karthik B., Baker, Darren J., Wu, Xiaosheng, Kang-Decker, Ningling, van Deursen, Jan M.
Publicado em 2003

Cdc20 Is Critical for Meiosis I and Fertility of Female Mice

Por Jin, Fang, Hamada, Masakazu, Malureanu, Liviu, Jeganathan, Karthik B., Zhou, Wei, Morbeck, Dean E., van Deursen, Jan M.
Publicado em 2010

Reduced Life- and Healthspan in Mice Carrying a Mono-Allelic BubR1 MVA Mutation

Por Wijshake, Tobias, Malureanu, Liviu A., Baker, Darren J., Jeganathan, Karthik B., van de Sluis, Bart, van Deursen, Jan M.
Publicado em 2012

BubR1 alterations that reinforce mitotic surveillance act against aneuploidy and cancer

Por Weaver, Robbyn L, Limzerwala, Jazeel F, Naylor, Ryan M, Jeganathan, Karthik B, Baker, Darren J, van Deursen, Jan M
Publicado no eLife (2016)

CAML loss causes anaphase failure and chromosome missegregation

Por Liu, Yu, Malureanu, Liviu, Jeganathan, Karthik B., Tran, David Dinh, Lindquist, Lonn D., van Deursen, Jan M., Bram, Richard J.
Publicado em 2009

Resolution of Sister Centromeres Requires RanBP2-Mediated SUMOylation of Topoisomerase IIα

Por Dawlaty, Meelad M., Malureanu, Liviu, Jeganathan, Karthik B., Kao, Esther, Sustmann, Claudio, Tahk, Samuel, Shuai, Ke, Grosschedl, Rudolf, van Deursen, Jan M.
Publicado em 2008

Ran-dependent docking of importin-β to RanBP2/Nup358 filaments is essential for protein import and cell viability

Por Hamada, Masakazu, Haeger, Anna, Jeganathan, Karthik B., van Ree, Janine H., Malureanu, Liviu, Wälde, Sarah, Joseph, Jomon, Kehlenbach, Ralph H., van Deursen, Jan M.
Publicado em 2011

Cdc20 hypomorphic mice fail to counteract de novo synthesis of cyclin B1 in mitosis

Por Malureanu, Liviu, Jeganathan, Karthik B., Jin, Fang, Baker, Darren J., van Ree, Janine H., Gullon, Oliver, Chen, Zheyan, Henley, John R., van Deursen, Jan M.
Publicado em 2010

Spartan deficiency causes genomic instability and progeroid phenotypes

Por Maskey, Reeja S., Kim, Myoung Shin, Baker, Darren J., Childs, Bennett, Malureanu, Liviu A., Jeganathan, Karthik B., Machida, Yuka, van Deursen, Jan M., Machida, Yuichi J.
Publicado no Nat Commun (2014)

SIRT2 induces the checkpoint kinase BubR1 to increase lifespan

Por North, Brian J, Rosenberg, Michael A, Jeganathan, Karthik B, Hafner, Angela V, Michan, Shaday, Dai, Jing, Baker, Darren J, Cen, Yana, Wu, Lindsay E, Sauve, Anthony A, van Deursen, Jan M, Rosenzweig, Anthony, Sinclair, David A
Publicado em 2014

Naturally occurring p16(Ink4a)-positive cells shorten healthy lifespan

Por Baker, Darren J., Childs, Bennett G., Durik, Matej, Wijers, Melinde E., Sieben, Cynthia J., Zhong, Jian, Saltness, Rachel, Jeganathan, Karthik B., Versoza, Grace C., Pezeshki, Abdul-Mohammad, Khazaie, Khashayarsha, Miller, Jordan D., van Deursen, Jan M.
Publicado no Nature (2016)

Increased expression of BubR1 protects against aneuploidy and cancer and extends healthy lifespan

Por Baker, Darren J., Dawlaty, Meelad M., Wijshake, Tobias, Jeganathan, Karthik B., Malureanu, Liviu, van Ree, Janine H., Crespo-Diaz, Ruben, Reyes, Santiago, Seaburg, Lauren, Shapiro, Virginia, Behfar, Atta, Terzic, Andre, van de Sluis, Bart, van Deursen, Jan M.
Publicado em 2012