Increased expression of BubR1 protects against aneuploidy and cancer and extends healthy lifespan

The BubR1 gene encodes for a mitotic regulator that ensures accurate segregation of chromosomes through its role in the mitotic checkpoint and the establishment of proper microtubule-kinetochore attachments. Germline mutations that reduce BubR1 abundance cause aneuploidy, shorten lifespan, and induc...

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Bibliographic Details
Main Authors: Baker, Darren J., Dawlaty, Meelad M., Wijshake, Tobias, Jeganathan, Karthik B., Malureanu, Liviu, van Ree, Janine H., Crespo-Diaz, Ruben, Reyes, Santiago, Seaburg, Lauren, Shapiro, Virginia, Behfar, Atta, Terzic, Andre, van de Sluis, Bart, van Deursen, Jan M.
Format: Artigo
Language:Inglês
Published: 2012
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3707109/
https://ncbi.nlm.nih.gov/pubmed/23242215
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncb2643
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