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Increased expression of BubR1 protects against aneuploidy and cancer and extends healthy lifespan
The BubR1 gene encodes for a mitotic regulator that ensures accurate segregation of chromosomes through its role in the mitotic checkpoint and the establishment of proper microtubule-kinetochore attachments. Germline mutations that reduce BubR1 abundance cause aneuploidy, shorten lifespan, and induc...
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| Main Authors: | , , , , , , , , , , , , , |
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| Format: | Artigo |
| Language: | Inglês |
| Published: |
2012
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3707109/ https://ncbi.nlm.nih.gov/pubmed/23242215 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncb2643 |
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