BubR1 alterations that reinforce mitotic surveillance act against aneuploidy and cancer

BubR1 is a key component of the spindle assembly checkpoint (SAC). Mutations that reduce BubR1 abundance cause aneuploidization and tumorigenesis in humans and mice, whereas BubR1 overexpression protects against these. However, how supranormal BubR1 expression exerts these beneficial physiological i...

Full description

Saved in:
Bibliographic Details
Published in:eLife
Main Authors: Weaver, Robbyn L, Limzerwala, Jazeel F, Naylor, Ryan M, Jeganathan, Karthik B, Baker, Darren J, van Deursen, Jan M
Format: Artigo
Language:Inglês
Published: eLife Sciences Publications, Ltd 2016
Subjects:
Cancer Biology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4987139/
https://ncbi.nlm.nih.gov/pubmed/27528194
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.16620
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items