BubR1 alterations that reinforce mitotic surveillance act against aneuploidy and cancer

BubR1 is a key component of the spindle assembly checkpoint (SAC). Mutations that reduce BubR1 abundance cause aneuploidization and tumorigenesis in humans and mice, whereas BubR1 overexpression protects against these. However, how supranormal BubR1 expression exerts these beneficial physiological i...

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Publicado en:eLife
Autores principales: Weaver, Robbyn L, Limzerwala, Jazeel F, Naylor, Ryan M, Jeganathan, Karthik B, Baker, Darren J, van Deursen, Jan M
Formato: Artigo
Lenguaje:Inglês
Publicado: eLife Sciences Publications, Ltd 2016
Materias:
Cancer Biology
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4987139/
https://ncbi.nlm.nih.gov/pubmed/27528194
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.16620
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