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BubR1 alterations that reinforce mitotic surveillance act against aneuploidy and cancer
BubR1 is a key component of the spindle assembly checkpoint (SAC). Mutations that reduce BubR1 abundance cause aneuploidization and tumorigenesis in humans and mice, whereas BubR1 overexpression protects against these. However, how supranormal BubR1 expression exerts these beneficial physiological i...
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| Publicado no: | eLife |
|---|---|
| Main Authors: | , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
eLife Sciences Publications, Ltd
2016
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4987139/ https://ncbi.nlm.nih.gov/pubmed/27528194 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.16620 |
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