SIRT2 induces the checkpoint kinase BubR1 to increase lifespan

Mice overexpressing the mitotic checkpoint kinase gene BubR1 live longer, whereas mice hypomorphic for BubR1 (BubR1(H/H)) live shorter and show signs of accelerated aging. As wild-type mice age, BubR1 levels decline in many tissues, a process that is proposed to underlie normal aging and age-related...

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Bibliographic Details
Main Authors: North, Brian J, Rosenberg, Michael A, Jeganathan, Karthik B, Hafner, Angela V, Michan, Shaday, Dai, Jing, Baker, Darren J, Cen, Yana, Wu, Lindsay E, Sauve, Anthony A, van Deursen, Jan M, Rosenzweig, Anthony, Sinclair, David A
Format: Artigo
Language:Inglês
Published: BlackWell Publishing Ltd 2014
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4194088/
https://ncbi.nlm.nih.gov/pubmed/24825348
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/embj.201386907
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