SIRT2 induces the checkpoint kinase BubR1 to increase lifespan

Mice overexpressing the mitotic checkpoint kinase gene BubR1 live longer, whereas mice hypomorphic for BubR1 (BubR1(H/H)) live shorter and show signs of accelerated aging. As wild-type mice age, BubR1 levels decline in many tissues, a process that is proposed to underlie normal aging and age-related...

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Xehetasun bibliografikoak
Egile Nagusiak: North, Brian J, Rosenberg, Michael A, Jeganathan, Karthik B, Hafner, Angela V, Michan, Shaday, Dai, Jing, Baker, Darren J, Cen, Yana, Wu, Lindsay E, Sauve, Anthony A, van Deursen, Jan M, Rosenzweig, Anthony, Sinclair, David A
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: BlackWell Publishing Ltd 2014
Gaiak:
Articles
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC4194088/
https://ncbi.nlm.nih.gov/pubmed/24825348
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/embj.201386907
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