Cdc20 hypomorphic mice fail to counteract de novo synthesis of cyclin B1 in mitosis

Cdc20 is an activator of the anaphase-promoting complex/cyclosome that initiates anaphase onset by ordering the destruction of cyclin B1 and securin in metaphase. To study the physiological significance of Cdc20 in higher eukaryotes, we generated hypomorphic mice that express small amounts of this e...

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Detalhes bibliográficos
Main Authors: Malureanu, Liviu, Jeganathan, Karthik B., Jin, Fang, Baker, Darren J., van Ree, Janine H., Gullon, Oliver, Chen, Zheyan, Henley, John R., van Deursen, Jan M.
Formato: Artigo
Idioma:Inglês
Publicado em: The Rockefeller University Press 2010
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2958469/
https://ncbi.nlm.nih.gov/pubmed/20956380
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.201003090
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