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Nuclear pore protein NUP88 activates anaphase-promoting complex to promote aneuploidy
The nuclear pore complex protein NUP88 is frequently elevated in aggressive human cancers and correlates with reduced patient survival; however, it is unclear whether and how NUP88 overexpression drives tumorigenesis. Here, we show that mice overexpressing NUP88 are cancer prone and form intestinal...
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| Publicado no: | J Clin Invest |
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| Main Authors: | , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Clinical Investigation
2016
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4731171/ https://ncbi.nlm.nih.gov/pubmed/26731471 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI82277 |
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