Disruption of the FG nucleoporin NUP98 causes selective changes in nuclear pore complex stoichiometry and function

The NUP98 gene encodes precursor proteins that generate two nucleoplasmically oriented nucleoporins, NUP98 and NUP96. By using gene targeting, we have selectively disrupted the murine NUP98 protein, leaving intact the expression and localization of NUP96. We show that NUP98 is essential for mouse ga...

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Detalhes bibliográficos

Publicado no:	Proc Natl Acad Sci U S A
Principais autores:	Wu, Xiaosheng, Kasper, Lawryn H., Mantcheva, Ralitsa T., Mantchev, George T., Springett, Margaret J., van Deursen, Jan M. A.
Formato:	Artigo
Idioma:	Inglês
Publicado em:	National Academy of Sciences 2001
Assuntos:	Biological Sciences
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC30629/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11248054/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.051631598
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