Disruption of the FG nucleoporin NUP98 causes selective changes in nuclear pore complex stoichiometry and function

The NUP98 gene encodes precursor proteins that generate two nucleoplasmically oriented nucleoporins, NUP98 and NUP96. By using gene targeting, we have selectively disrupted the murine NUP98 protein, leaving intact the expression and localization of NUP96. We show that NUP98 is essential for mouse ga...

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Publié dans:	Proc Natl Acad Sci U S A
Auteurs principaux:	Wu, Xiaosheng, Kasper, Lawryn H., Mantcheva, Ralitsa T., Mantchev, George T., Springett, Margaret J., van Deursen, Jan M. A.
Format:	Artigo
Langue:	Inglês
Publié:	National Academy of Sciences 2001
Sujets:	Biological Sciences
Accès en ligne:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC30629/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11248054/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.051631598
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