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Bub1 kinase activity drives error correction and mitotic checkpoint control but not tumor suppression

The mitotic checkpoint protein Bub1 is essential for embryogenesis and survival of proliferating cells, and bidirectional deviations from its normal level of expression cause chromosome missegregation, aneuploidy, and cancer predisposition in mice. To provide insight into the physiological significa...

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Detalhes bibliográficos
Main Authors: Ricke, Robin M., Jeganathan, Karthik B., Malureanu, Liviu, Harrison, Andrew M., van Deursen, Jan M.
Formato: Artigo
Idioma:Inglês
Publicado em: The Rockefeller University Press 2012
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3518220/
https://ncbi.nlm.nih.gov/pubmed/23209306
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.201205115
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