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Bub1 kinase activity drives error correction and mitotic checkpoint control but not tumor suppression
The mitotic checkpoint protein Bub1 is essential for embryogenesis and survival of proliferating cells, and bidirectional deviations from its normal level of expression cause chromosome missegregation, aneuploidy, and cancer predisposition in mice. To provide insight into the physiological significa...
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| Main Authors: | , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
The Rockefeller University Press
2012
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3518220/ https://ncbi.nlm.nih.gov/pubmed/23209306 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.201205115 |
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