Bub1 kinase activity drives error correction and mitotic checkpoint control but not tumor suppression

The mitotic checkpoint protein Bub1 is essential for embryogenesis and survival of proliferating cells, and bidirectional deviations from its normal level of expression cause chromosome missegregation, aneuploidy, and cancer predisposition in mice. To provide insight into the physiological significa...

Full description

Saved in:
Bibliographic Details
Main Authors: Ricke, Robin M., Jeganathan, Karthik B., Malureanu, Liviu, Harrison, Andrew M., van Deursen, Jan M.
Format: Artigo
Language:Inglês
Published: The Rockefeller University Press 2012
Subjects:
Research Articles
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3518220/
https://ncbi.nlm.nih.gov/pubmed/23209306
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.201205115
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items