Resolution of Sister Centromeres Requires RanBP2-Mediated SUMOylation of Topoisomerase IIα

RanBP2 is a nucleoporin with SUMO E3 ligase activity that functions in both nucleocytoplasmic transport and mitosis. However, the biological relevance of RanBP2 and the in vivo targets of its E3 ligase activity are unknown. Here we show that animals with low amounts of RanBP2 develop severe aneuploi...

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Main Authors: Dawlaty, Meelad M., Malureanu, Liviu, Jeganathan, Karthik B., Kao, Esther, Sustmann, Claudio, Tahk, Samuel, Shuai, Ke, Grosschedl, Rudolf, van Deursen, Jan M.
Format: Artigo
Jezik:Inglês
Izdano: 2008
Teme:
Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2693193/
https://ncbi.nlm.nih.gov/pubmed/18394993
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2008.01.045
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