Resolution of Sister Centromeres Requires RanBP2-Mediated SUMOylation of Topoisomerase IIα

RanBP2 is a nucleoporin with SUMO E3 ligase activity that functions in both nucleocytoplasmic transport and mitosis. However, the biological relevance of RanBP2 and the in vivo targets of its E3 ligase activity are unknown. Here we show that animals with low amounts of RanBP2 develop severe aneuploi...

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Main Authors: Dawlaty, Meelad M., Malureanu, Liviu, Jeganathan, Karthik B., Kao, Esther, Sustmann, Claudio, Tahk, Samuel, Shuai, Ke, Grosschedl, Rudolf, van Deursen, Jan M.
Formato: Artigo
Idioma:Inglês
Publicado em: 2008
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2693193/
https://ncbi.nlm.nih.gov/pubmed/18394993
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2008.01.045
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