Temperature dependent 2(nd) derivative absorbance spectroscopy of aromatic amino acids as a probe of protein dynamics

Por Esfandiary, Reza, Hunjan, Jagtar S, Lushington, Gerald H, Joshi, Sangeeta B, Middaugh, C Russell
Publicado em 2009

Improved data visualization techniques for analyzing macromolecule structural changes

Por Kim, Jae Hyun, Iyer, Vidyashankara, Joshi, Sangeeta B, Volkin, David B, Middaugh, C Russell
Publicado em 2012

Multidimensional Methods for the Formulation of Biopharmaceuticals and Vaccines

Por Maddux, Nathaniel R., Joshi, Sangeeta B., Volkin, David B., Ralston, John P., Middaugh, C. Russell
Publicado em 2011

Structural Characterization of IgG1 mAb Aggregates and Particles Generated under Various Stress Conditions

Por Telikepalli, Srivalli N., Kumru, Ozan S., Kalonia, Cavan, Esfandiary, Reza, Joshi, Sangeeta B., Middaugh, C. Russell, Volkin, David B.
Publicado em 2014

Formulation and Immunogenicity studies of Type III Secretion System needle antigens as Vaccine Candidates

Por Barrett, Brooke S., Markham, Aaron P., Esfandiary, Reza, Picking, Wendy L., Picking, William D., Joshi, Sangeeta B., Middaugh, C. Russell
Publicado em 2010

Understanding the relevance of local conformational stability and dynamics to the aggregation propensity of an IgG1 and IgG2 monoclonal antibodies

Por Thakkar, Santosh V, Sahni, Neha, Joshi, Sangeeta B, Kerwin, Bruce A, He, Feng, Volkin, David B, Middaugh, C Russell
Publicado em 2013

Parathyroid hormone is a heparin/polyanion binding protein: Binding energetics and structure modification

Por Kamerzell, Tim J., Joshi, Sangeeta B., McClean, Donald, Peplinskie, Lori, Toney, Karen, Papac, Damon, Li, Meili, Middaugh, C. Russell
Publicado em 2007

Biophysical and Stabilization Studies of the Chlamydia trachomatis Mouse Pneumonitis Major Outer Membrane Protein

Por Cai, Sumin, He, Feng, Samra, Hardeep S., de la Maza, Luis M., Bottazzi, Maria E., Joshi, Sangeeta B., Middaugh, C. Russell
Publicado em 2009

Comparison of the Structural Stability and Dynamic Properties of Recombinant Anthrax Protective Antigen and its 2-Fluorohistidine Labeled Analogue

Por Hu, Lei, Joshi, Sangeeta B., Andra, Kiran K., Thakkar, Santosh V., Volkin, David B., Bann, James G., Middaugh, C. Russell
Publicado em 2012

Development of a candidate stabilizing formulation for bulk storage of a double mutant heat labile toxin (dmLT) protein based adjuvant

Por Toprani, Vishal M., Sahni, Neha, Hickey, John M., Robertson, George A., Middaugh, C. Russell, Joshi, Sangeeta B., Volkin, David B.
Publicado no Vaccine (2017)

An empirical phase diagram approach to investigate conformational stability of “second-generation” functional mutants of acidic fibroblast growth factor-1

Por Alsenaidy, Mohammad A, Wang, Tingting, Kim, Jae Hyun, Joshi, Sangeeta B, Lee, Jihun, Blaber, Michael, Volkin, David B, Middaugh, C Russell
Publicado em 2012

Physical stability comparisons of IgG1-Fc variants: effects of N-glycosylation site occupancy and Asp/Gln residues at site Asn 297

Por ALSENAIDY, MOHAMMAD A., OKBAZGHI, SOLOMON Z., KIM, JAE HYUN, JOSHI, SANGEETA B., MIDDAUGH, C. RUSSELL, TOLBERT, THOMAS J., VOLKIN, DAVID B.
Publicado no J Pharm Sci (2014)

Effect of acrylodan conjugation and forced oxidation on the structural integrity, conformational stability, and binding activity of a glucose binding protein SM4 used in a prototyp...

Por Hickey, John M., Sahni, Neha, Chaudhuri, Rajoshi, D'Souza, Ajit, Metters, Andrew, Joshi, Sangeeta B., Russell Middaugh, C., Volkin, David B.
Publicado no Protein Sci (2017)

Probing protein structure and dynamics by second-derivative ultraviolet absorption analysis of cation–π interactions

Por Lucas, Laura H., Ersoy, Baran A., Kueltzo, Lisa A., Joshi, Sangeeta B., Brandau, Duane T., Thyagarajapuram, Nagarajan, Peek, Laura J., Middaugh, C. Russell
Publicado em 2006

Structural Characterization and Physicochemical Stability Profile of a Double Mutant Heat Labile Toxin Protein Based Adjuvant

Por Toprani, Vishal M., Hickey, John M., Sahni, Neha, Toth, Ronald T., Robertson, George A., Middaugh, C. Russell, Joshi, Sangeeta B., Volkin, David B.
Publicado no J Pharm Sci (2017)

Adsorption of recombinant poxvirus L1-protein to aluminum hydroxide/CpG vaccine adjuvants enhances immune responses and protection of mice from vaccinia virus challenge

Por Xiao, Yuhong, Zeng, Yuhong, Alexander, Edward, Mehta, Shyam, Joshi, Sangeeta B., Buchman, George W., Volkin, David B., Middaugh, C. Russell, Isaacs, Stuart N.
Publicado em 2012

High-Throughput Biophysical Analysis and Data Visualization of Conformational Stability of an IgG1 Monoclonal Antibody (mAb) After Deglycosylation

Por Alsenaidy, Mohammad A., Kim, Jae Hyun, Majumdar, Ranajoy, Weis, David D., Joshi, Sangeeta B., Tolbert, Thomas J., Middaugh, C. Russell, Volkin, David B.
Publicado em 2013

Oligomeric states of the Shigella translocator protein IpaB provide structural insights into formation of the type III secretion translocon

Por Dickenson, Nicholas E, Choudhari, Shyamal P, Adam, Philip R, Kramer, Ryan M, Joshi, Sangeeta B, Middaugh, C Russell, Picking, Wendy L, Picking, William D
Publicado em 2013

Using Empirical Phase Diagrams to Understand the Role of Intramolecular Dynamics in Immunoglobulin G Stability

Por Ramsey, Joshua D., Gill, Michelle L., Kamerzell, Tim J., Price, E. Shane, Joshi, Sangeeta B., Bishop, Steven M., Oliver, Cynthia N., Middaugh, C. Russell
Publicado em 2009

Production, characterization, and biological evaluation of well-defined IgG1 Fc glycoforms as a model system for biosimilarity analysis

Por Okbazghi, Solomon Z., More, Apurva S., White, Derek R., Duan, Shaofeng, Shah, Ishan S., Joshi, Sangeeta B., Middaugh, C. Russell, Volkin, David B., Tolbert, Thomas J.
Publicado no J Pharm Sci (2016)