Production, characterization, and biological evaluation of well-defined IgG1 Fc glycoforms as a model system for biosimilarity analysis

Four different well-defined IgG1 Fc glycoforms are proposed as a model system to examine important biological and physicochemical features for protein drug biosimilar analyses. The IgG1 Fc glycoforms were produced by yeast expression combined with in vitro enzymatic synthesis as a series of sequenti...

Full description

Saved in:
Bibliographic Details
Published in:J Pharm Sci
Main Authors: Okbazghi, Solomon Z., More, Apurva S., White, Derek R., Duan, Shaofeng, Shah, Ishan S., Joshi, Sangeeta B., Middaugh, C. Russell, Volkin, David B., Tolbert, Thomas J.
Format: Artigo
Language:Inglês
Published: 2016
Subjects:
Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4752726/
https://ncbi.nlm.nih.gov/pubmed/26869419
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.xphs.2015.11.003
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items