Localizing a gate in CFTR

Por Gao, Xiaolong, Hwang, Tzyh-Chang
Publicado no Proc Natl Acad Sci U S A (2015)

Spatial positioning of CFTR’s pore-lining residues affirms an asymmetrical contribution of transmembrane segments to the anion permeation pathway

Por Gao, Xiaolong, Hwang, Tzyh-Chang
Publicado no J Gen Physiol (2016)

Electrostatic tuning of the pre- and post-hydrolytic open states in CFTR

Por Zhang, Jingyao, Hwang, Tzyh-Chang
Publicado no J Gen Physiol (2017)

Gating of the CFTR Cl(−) channel by ATP-driven nucleotide-binding domain dimerisation

Por Hwang, Tzyh-Chang, Sheppard, David N
Publicado em 2009

The CFTR Ion Channel: Gating, Regulation, and Anion Permeation

Por Hwang, Tzyh-Chang, Kirk, Kevin L.
Publicado em 2013

Vx-770 potentiates CFTR function by promoting decoupling between the gating cycle and ATP hydrolysis cycle

Por Jih, Kang-Yang, Hwang, Tzyh-Chang
Publicado em 2013

Nonequilibrium Gating of CFTR on an Equilibrium Theme

Por Jih, Kang-Yang, Hwang, Tzyh-Chang
Publicado no Physiology (Bethesda) (2012)

Probing an Open CFTR Pore with Organic Anion Blockers

Por Zhou, Zhen, Hu, Shenghui, Hwang, Tzyh-Chang
Publicado em 2002

Voltage-dependent flickery block of an open cystic fibrosis transmembrane conductance regulator (CFTR) channel pore

Por Zhou, Zhen, Hu, Shenghui, Hwang, Tzyh-Chang
Publicado em 2001

Dual roles of the sixth transmembrane segment of the CFTR chloride channel in gating and permeation

Por Bai, Yonghong, Li, Min, Hwang, Tzyh-Chang
Publicado em 2010

Structural basis for the channel function of a degraded ABC transporter, CFTR (ABCC7)

Por Bai, Yonghong, Li, Min, Hwang, Tzyh-Chang
Publicado em 2011

Cysteine Scanning of CFTR’s First Transmembrane Segment Reveals Its Plausible Roles in Gating and Permeation

Por Gao, Xiaolong, Bai, Yonghong, Hwang, Tzyh-Chang
Publicado em 2013

The Relationship between Camp, Ca(2)+, and Transport of Cftr to the Plasma Membrane

Por Chen, Peng, Hwang, Tzyh-Chang, Gillis, Kevin D.
Publicado em 2001

Stable ATP binding mediated by a partial NBD dimer of the CFTR chloride channel

Por Tsai, Ming-Feng, Li, Min, Hwang, Tzyh-Chang
Publicado em 2010

Nonintegral stoichiometry in CFTR gating revealed by a pore-lining mutation

Por Jih, Kang-Yang, Sohma, Yoshiro, Hwang, Tzyh-Chang
Publicado em 2012

Prevalence and medical management of erectile dysfunction in Asia

Por Park, Kwangsung, Hwang, Eu Chang, Kim, Sun-Ouck
Publicado em 2011

On the mechanism of gating defects caused by the R117H mutation in cystic fibrosis transmembrane conductance regulator

Por Yu, Ying‐Chun, Sohma, Yoshiro, Hwang, Tzyh‐Chang
Publicado no J Physiol (2016)

Curcumin and Genistein: the Combined Effects on Disease-associated CFTR Mutants and their Clinical Implications

Por Sohma, Yoshiro, Yu, Ying-Chun, Hwang, Tzyh-Chang
Publicado no Curr Pharm Des (2013)

Synergistic Potentiation of Cystic Fibrosis Transmembrane Conductance Regulator Gating by Two Chemically Distinct Potentiators, Ivacaftor (VX-770) and 5-Nitro-2-(3-Phenylpropylamin...

Por Lin, Wen-Ying, Sohma, Yoshiro, Hwang, Tzyh-Chang
Publicado no Mol Pharmacol (2016)

Epicardial Adipose Tissue Contributes to the Development of Non-Calcified Coronary Plaque: A 5-Year Computed Tomography Follow-up Study

Por Hwang, In-Chang, Park, Hyo Eun, Choi, Su-Yeon
Publicado no J Atheroscler Thromb (2017)