Endogenous lipid activated G protein-coupled receptors: Emerging structural features from crystallography and molecular dynamics simulations

Por Hurst, Dow P., Schmeisser, Marianne, Reggio, Patricia H.
Publicado em 2013

Molecular Targets of the Phytocannabinoids-A Complex Picture

Por Morales, Paula, Hurst, Dow P., Reggio, Patricia H.
Publicado no Prog Chem Org Nat Prod (2017)

Methods for the development of in silico GPCR models

Por Morales, Paula, Hurst, Dow P., Reggio, Patricia H.
Publicado no Methods Enzymol (2017)

Molecular Dynamics Methodologies for Probing Cannabinoid Ligand/Receptor Interaction

Por Lynch, Diane L., Hurst, Dow P., Shore, Derek M., Pitman, Mike C., Reggio, Patricia H.
Publicado no Methods Enzymol (2017)

Residues accessible in the binding site crevice of transmembrane helix 6 of the CB2 cannabinoid receptor()

Por Nebane, Ntsang M., Hurst, Dow P., Carrasquer, Carl A., Qiao, Zhuanhong, Reggio, Patricia H., Song, Zhao-Hui
Publicado no Biochemistry (2008)

Structure-activity relationships of benzothiazole GPR35 antagonists

Por Abdalhameed, Manahil M., Zhao, Pingwei, Hurst, Dow P., Reggio, Patricia H., Abood, Mary E., Croatt, Mitchell P.
Publicado no Bioorg Med Chem Lett (2016)

Identification of crucial amino acid residues involved in agonist signaling at the GPR55 receptor

Por Lingerfelt, Mary A., Zhao, Pingwei, Sharir, Haleli P., Hurst, Dow P., Reggio, Patricia H., Abood, Mary E.
Publicado no Biochemistry (2017)

Synthesis and Pharmacology of 1-Methoxy Analogs of CP-47,497

Por Huffman, John W., Hepburn, Seon A., Reggio, Patricia H., Hurst, Dow P., Wiley, Jenny L., Martin, Billy R.
Publicado em 2010

Isolation, semisynthesis, covalent docking and transforming growth factor beta-activated kinase 1 (TAK1)-inhibitory activities of (5Z)-7-oxozeaenol analogues

Por Fakhouri, Lara, El-Elimat, Tamam, Hurst, Dow P., Reggio, Patricia H., Pearce, Cedric J., Oberlies, Nicholas H., Croatt, Mitchell P.
Publicado no Bioorg Med Chem (2015)

A Lipid Pathway for Ligand Binding Is Necessary for a Cannabinoid G Protein-coupled Receptor

Por Hurst, Dow P., Grossfield, Alan, Lynch, Diane L., Feller, Scott, Romo, Tod D., Gawrisch, Klaus, Pitman, Michael C., Reggio, Patricia H.
Publicado em 2010

(4-(Bis(4-Fluorophenyl)Methyl)Piperazin-1-yl)(Cyclohexyl)Methanone Hydrochloride (LDK1229): A New Cannabinoid CB(1) Receptor Inverse Agonist from the Class of Benzhydryl Piperazine...

Por Mahmoud, Mariam M., Olszewska, Teresa, Liu, Hui, Shore, Derek M., Hurst, Dow P., Reggio, Patricia H., Lu, Dai, Kendall, Debra A.
Publicado no Mol Pharmacol (2015)

Palmitoylation and membrane cholesterol stabilize μ-opioid receptor homodimerization and G protein coupling

Por Zheng Hui, Pearsall Elizabeth A, Hurst Dow P, Zhang Yuhan, Chu Ji, Zhou Yali, Reggio Patricia H, Loh Horace H, Law Ping-Yee
Publicado em 2012-03-01

Palmitoylation and membrane cholesterol stabilize μ-opioid receptor homodimerization and G protein coupling

Por Zheng, Hui, Pearsall, Elizabeth A, Hurst, Dow P, Zhang, Yuhan, Chu, Ji, Zhou, Yali, Reggio, Patricia H, Loh, Horace H, Law, Ping-Yee
Publicado em 2012

Global Fold of Human Cannabinoid Type 2 Receptor Probed by Solid-State (13)C-, (15)N-MAS NMR and Molecular Dynamics Simulations

Por Kimura, Tomohiro, Vukoti, Krishna, Lynch, Diane L., Hurst, Dow P., Grossfield, Alan, Pitman, Michael C., Reggio, Patricia H., Yeliseev, Alexei A., Gawrisch, Klaus
Publicado em 2013

Crucial Positively Charged Residues for Ligand Activation of the GPR35 Receptor

Por Zhao, Pingwei, Lane, Tom R., Gao, Helen G. L., Hurst, Dow P., Kotsikorou, Evangelia, Le, Long, Brailoiu, Eugen, Reggio, Patricia H., Abood, Mary E.
Publicado em 2014

Structural Basis of G Protein-coupled Receptor-G(i) Protein Interaction: FORMATION OF THE CANNABINOID CB(2) RECEPTOR-G(i) PROTEIN COMPLEX

Por Mnpotra, Jagjeet S., Qiao, Zhuanhong, Cai, Jian, Lynch, Diane L., Grossfield, Alan, Leioatts, Nicholas, Hurst, Dow P., Pitman, Michael C., Song, Zhao-Hui, Reggio, Patricia H.
Publicado em 2014

Analogs of JHU75528, a PET ligand for imaging of cerebral cannabinoid receptors (CB1): development of ligands with optimized lipophilicity and binding affinity

Por Fan, Hong, Kotsikorou, Evangelia, Hoffman, Alexander F., Ravert, Hayden T., Holt, Daniel, Hurst, Dow P., Lupica, Carl R., Reggio, Patricia H., Dannals, Robert F., Horti, Andrew G.
Publicado em 2008

The Importance of Hydrogen Bonding and Aromatic Stacking to the Affinity and Efficacy of Cannabinoid Receptor CB(2) Antagonist, 5-(4-Chloro-3-methyl-phenyl)-1-(4-methyl-benzyl)-1H-...

Por Kotsikorou, Evangelia, Navas, Frank, Roche, Michael J., Gilliam, Anne F., Thomas, Brian, Seltzman, Herbert H., Kumar, Pritesh, Song, Zhao-Hui, Hurst, Dow P., Lynch, Diane L., Reggio, Patricia H.
Publicado em 2013

Chromenopyrazole, a Versatile Cannabinoid Scaffold with in Vivo Activity in a Model of Multiple Sclerosis

Por Morales, Paula, Gómez-Cañas, María, Navarro, Gemma, Hurst, Dow P., Carrillo-Salinas, Francisco J., Lagartera, Laura, Pazos, Ruth, Goya, Pilar, Reggio, Patricia H., Guaza, Carmen, Franco, Rafael, Fernández-Ruiz, Javier, Jagerovic, Nadine
Publicado no J Med Chem (2016)

Design, synthesis and biological evaluation of GPR55 agonists

Por Fakhouri, Lara, Cook, Christopher D., Al-Huniti, Mohommed H., Console-Bram, Linda M., Hurst, Dow P., Spano, Michael B. S., Nasrallah, Daniel J., Caron, Marc G., Barak, Larry S., Reggio, Patricia H., Abood, Mary E., Croatt, Mitchell P.
Publicado no Bioorg Med Chem (2017)