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Structure-activity relationships of benzothiazole GPR35 antagonists
The first structure-activity relationships for a benzothiazole scaffold acting as an antagonist at GPR35 is presented. Analogues were designed based on a lead compound that was previously determined to have selective activity as a GPR35 antagonist. The synthetic route was modular in nature to indepe...
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| Publicado no: | Bioorg Med Chem Lett |
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| Main Authors: | , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2016
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5335871/ https://ncbi.nlm.nih.gov/pubmed/27989666 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2016.12.012 |
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