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Structure-activity relationships of benzothiazole GPR35 antagonists

The first structure-activity relationships for a benzothiazole scaffold acting as an antagonist at GPR35 is presented. Analogues were designed based on a lead compound that was previously determined to have selective activity as a GPR35 antagonist. The synthetic route was modular in nature to indepe...

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Bibliografische gegevens
Gepubliceerd in:Bioorg Med Chem Lett
Hoofdauteurs: Abdalhameed, Manahil M., Zhao, Pingwei, Hurst, Dow P., Reggio, Patricia H., Abood, Mary E., Croatt, Mitchell P.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2016
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5335871/
https://ncbi.nlm.nih.gov/pubmed/27989666
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2016.12.012
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