Crucial Positively Charged Residues for Ligand Activation of the GPR35 Receptor

GPR35 is a G protein-coupled receptor expressed in the immune, gastrointestinal, and nervous systems in gastric carcinomas and is implicated in heart failure and pain perception. We investigated residues in GPR35 responsible for ligand activation and the receptor structure in the active state. GPR35...

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Bibliographic Details
Main Authors:	Zhao, Pingwei, Lane, Tom R., Gao, Helen G. L., Hurst, Dow P., Kotsikorou, Evangelia, Le, Long, Brailoiu, Eugen, Reggio, Patricia H., Abood, Mary E.
Format:	Artigo
Language:	Inglês
Published:	American Society for Biochemistry and Molecular Biology 2014
Subjects:	Signal Transduction
Online Access:	https://ncbi.nlm.nih.gov/pmc/articles/PMC3916562/ https://ncbi.nlm.nih.gov/pubmed/24347166 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.508382
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Crucial Positively Charged Residues for Ligand Activation of the GPR35 Receptor

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