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Crucial Positively Charged Residues for Ligand Activation of the GPR35 Receptor

GPR35 is a G protein-coupled receptor expressed in the immune, gastrointestinal, and nervous systems in gastric carcinomas and is implicated in heart failure and pain perception. We investigated residues in GPR35 responsible for ligand activation and the receptor structure in the active state. GPR35...

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Detalhes bibliográficos
Main Authors: Zhao, Pingwei, Lane, Tom R., Gao, Helen G. L., Hurst, Dow P., Kotsikorou, Evangelia, Le, Long, Brailoiu, Eugen, Reggio, Patricia H., Abood, Mary E.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2014
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3916562/
https://ncbi.nlm.nih.gov/pubmed/24347166
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.508382
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