Chromenopyrazole, a Versatile Cannabinoid Scaffold with in Vivo Activity in a Model of Multiple Sclerosis

A combination of molecular modeling and structure–activity relationship studies has been used to fine-tune CB(2) selectivity in the chromenopyrazole ring, a versatile CB(1)/CB(2) cannabinoid scaffold. Thus, a series of 36 new derivatives covering a wide range of structural diversity has been synthes...

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Detalhes bibliográficos
Publicado no:J Med Chem
Main Authors: Morales, Paula, Gómez-Cañas, María, Navarro, Gemma, Hurst, Dow P., Carrillo-Salinas, Francisco J., Lagartera, Laura, Pazos, Ruth, Goya, Pilar, Reggio, Patricia H., Guaza, Carmen, Franco, Rafael, Fernández-Ruiz, Javier, Jagerovic, Nadine
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5321205/
https://ncbi.nlm.nih.gov/pubmed/27309150
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.jmedchem.6b00397
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